Description

A nucleobase analogue that is cytosine in which the hydrogen at position 5 is replaced by a carboxy group.

Chemical properties

Chemical formula Net charge Average mass
C5H5N3O3 0 155.11150
5-carboxycytosine

Recommended notation

Name 5-carboxylcytosine
Abbreviation 5caC
Symbol c
Complement guanine:5-carboxylcytosine
Symbol 4

Nomenclature

IUPAC SMILES Synonyms
4-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid Nc1nc(=O)[nH]cc1C(O)=O
  • 4-amino-2-oxopyrimidine-5-carboxylic acid
  • 5-carboxylcytosine
  • cytosine-5-carboxylic acid

Mapping techniques

Method Method detail Resolution Enrichment or limitation References
CAB-seq chemical conversion single-base
caMAB-seq chemical conversion single-base

Nature

Origin Function Functional detail Organisms References
natural demethylation intermediate and possible epigenetic mark
  • Homo sapiens
  • Mus musculus