Description

A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Chemical properties

Chemical formula Net charge Average mass
C4H3FN2O2 0 130.07730
5-fluorouracil

Nomenclature

IUPAC SMILES Synonyms
5-fluoropyrimidine-2,4(1H,3H)-dione, 5-fluorouracil Fc1c[nH]c(=O)[nH]c1=O
  • 5-fu
  • 5-fluoracil
  • fluorouracil
  • fluorouracilum
  • 5-fluoropyrimidine-2,4-dione
  • fluorouracilo