Hoffman research group
- Michael M. Hoffman
- Senior Scientist (principal investigator)
- Computational Biology and Medicine Program
- Princess Margaret Cancer Centre
- University Health Network
- Associate Professor (status-only)
- Computational Biology Group
- Department of Computer Science
- University of Toronto
We develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.
Publications
Software
- Segway: semi-automated genomic annotation
- Segtools: segmentation analysis and graphics
- Genomedata: efficient storage and retrieval
- Umap and Bismap: tools for quantifying mappability of the genome and methylome
- BEHST: biological enrichment of hidden sequence targets
- Virchip: predicting transcription factor binding by learning from the transcriptome
- PeaKO: finding transcription factor binding motifs using knockout controls
Databases
- DNAmod: the DNA modification database
Join the lab
People
Meet the team- Michael Hoffman
- Eric Roberts
- Coby Viner
- Linh Huynh
- Annie Lu
- Luomeng Tan
- Mary Agopian
- Gergely Pap
- Yahan Zhang
- Natalia Mukhina
News
- 2024-10-03: Eric releases Genomedata 1.7.3
- 2024-05-07: Mickael and Michael are co-authors on "Annotation of nuclear lncRNAs based on chromatin interactions", an article in PLOS ONE.
- 2024-04-16: Mickael is a co-author on "TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods", an article on BMJ.
- 2024-03-18: Michael presents a selected talk on "Human papillomavirus integration transforms chromatin to drive oncogenesis" at RECOMB-CCB 2024.
- 2024-03-01: Isaiah is a recipient of the 2024 T-CAIREM Summer Research Program award.
- 2024-01-08: Coby and Michael are co-authors on "Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet", an article that has been published in Genome Biology.
- News archive
Contact
- Twitter: @michaelhoffman
- LinkedIn: michaelmhoffman