Hoffman research group
- Michael M. Hoffman
- Senior Scientist (principal investigator)
- Computational Biology and Medicine Program
- Princess Margaret Cancer Centre
- University Health Network
We develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.
Publications
Software
- Segway: semi-automated genomic annotation
- Segtools: segmentation analysis and graphics
- Genomedata: efficient storage and retrieval
- Umap and Bismap: tools for quantifying mappability of the genome and methylome
- BEHST: biological enrichment of hidden sequence targets
- Virchip: predicting transcription factor binding by learning from the transcriptome
- PeaKO: finding transcription factor binding motifs using knockout controls
Databases
- DNAmod: the DNA modification database
Join the lab
People
Meet the team- Michael Hoffman
- Eric Roberts
- Luomeng Tan
- Mary Agopian
- Yahan Zhang
- Natalia Mukhina
News
- 2026-01-22: Michael is a guest lecturer in the MBP1413H 2026 graduate course entitled "Biomedical Applications of Artificial Intelligence".
- 2025-12-19: Michael is a co-author on a paper titled "Simulating cell-free chromatin using preclinical cancer models for liquid biopsy applications, on iScience.
- 2025-11-17: Gergely and Michael are members of the Inferring Binding Specificities (IBIS) Consortium, an author of "Inferring binding specificities of human transcription factors with the wisdom of crowds", on bioRxiv.
- 2025-09-25: Michael is a co-author of the article titled "A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes" that has been accepted by Nature Cancer.
- 2025-09-05: Michael is a speaker and facilitator at the Early Career Researcher Pre-TMM event, part of the Till & McCulloch Meetings (TMM2025), taking place in Ottawa, ON, November 2, 2025.
- 2025-09-02: Eric releases Genomedata 1.7.4.
- News archive
Contact
- Twitter: @michaelhoffman
- LinkedIn: michaelmhoffman