Hoffman research group
- Michael M. Hoffman
- Scientist (principal investigator)
- Research
- Princess Margaret Cancer Centre
- University Health Network
- Associate Professor (status-only)
- Computational Biology Group
- Department of Computer Science
- University of Toronto
We develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.
Publications
Software
- Segway: semi-automated genomic annotation
- Segtools: segmentation analysis and graphics
- Genomedata: efficient storage and retrieval
- Umap and Bismap: tools for quantifying mappability of the genome and methylome
- BEHST: biological enrichment of hidden sequence targets
- Virchip: predicting transcription factor binding by learning from the transcriptome
- PeaKO: finding transcription factor binding motifs using knockout controls
Databases
- DNAmod: the DNA modification database
Join the lab
People
Meet the team- Michael Hoffman
- Eric Roberts
- Coby Viner
- Mehran Karimzadeh
- Jai Sood
- Mickael Mendez
- Rachel Chan
- Danielle Denisko
- Francis Nguyen
- Samantha Wilson
- Matthew McNeil
- Yi Nian (Jeffrey) Niu
- Siddharth Reed
- Yushan (Ida) Liu
- Michael Wrana
- Natalia Mukhina
News
- 2020-07-16: Eric releases Segway 3.0.1.
- 2020-07-06: Michael is a guest mentor for 2020 Trainee Network session at KITE Three Minute Trainee Competition.
- 2020-07-02: Michael becomes a Canadian citizen.
- 2020-06-19: Danielle is joining the Bioinformatics and Integrative Genomics (BIG) PhD program at Harvard.
- 2020-06-19: Hoffman Lab announces an update to DNAmod.
- 2020-06-15: Michael’s academic appointment with the Department of Medical Biophysics, University of Toronto, is renewed.
- News archive
Contact
- Twitter: @michaelhoffman
- LinkedIn: michaelmhoffman