Hoffman research group
- Michael M. Hoffman
- Scientist (principal investigator)
- Research
- Princess Margaret Cancer Centre
- University Health Network
- Assistant Professor (status-only)
- Computational Biology Group
- Department of Computer Science
- University of Toronto
We develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.
Publications
Software
- Segway: semi-automated genomic annotation
- Segtools: segmentation analysis and graphics
- Genomedata: efficient storage and retrieval
- Umap and Bismap: tools for quantifying mappability of the genome and methylome
- BEHST: biological enrichment of hidden sequence targets
- Virchip: predicting transcription factor binding by learning from the transcriptome
- PeaKO: finding transcription factor binding motifs using knockout controls
Databases
- DNAmod: the DNA modification database
Join the lab
People
Meet the team- Michael Hoffman
- Eric Roberts
- Coby Viner
- Mehran Karimzadeh
- Jai Sood
- Mickael Mendez
- Rachel Chan
- Danielle Denisko
- Francis Nguyen
- Samantha Wilson
- Matthew McNeil
- Yi Nian (Jeffrey) Niu
- Siddharth Reed
- Yushan (Ida) Liu
- Michael Wrana
- Natalia Mukhina
News
- 2020-04-03: Michael will be promoted to Associate Professor at the University of Toronto Faculty of Medicine on July 1, 2020.
- 2020-03-10: Michael is a co-author of "The importance of transparency and reproducibility in artificial intelligence research", a preprint on arXiv
- 2020-02-13: Michael is the representative for Medical Biophysics on the program committee of the Collaborative Graduate Specialization Program in Genome Biology and Bioinformatics (GBB), University of Toronto.
- 2020-02-13: Mehran and Michael are the co-authors of "Viral integration transforms chromatin to drive oncogenesis", a preprint on bioRxiv Bioinformatics.
- 2020-02-07: Michael is a guest lecturer on the CBW Pathway Workshop where he will teach the Regulatory Network Analysis lecture on July 28th, 2020.
- 2020-02-03: Rachel, Matthew, Eric, Mickael, and Michael are the co-authors of "Semi-supervised segmentation and genome annotation", a preprint on bioRxiv Bioinformatics.
- News archive
Contact
- Twitter: @michaelhoffman
- LinkedIn: michaelmhoffman