Hoffman research group
- Michael M. Hoffman
- Senior Scientist (principal investigator)
- Research
- Princess Margaret Cancer Centre
- University Health Network
- Associate Professor (status-only)
- Computational Biology Group
- Department of Computer Science
- University of Toronto
We develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.
Publications
Software
- Segway: semi-automated genomic annotation
- Segtools: segmentation analysis and graphics
- Genomedata: efficient storage and retrieval
- Umap and Bismap: tools for quantifying mappability of the genome and methylome
- BEHST: biological enrichment of hidden sequence targets
- Virchip: predicting transcription factor binding by learning from the transcriptome
- PeaKO: finding transcription factor binding motifs using knockout controls
Databases
- DNAmod: the DNA modification database
Join the lab
People
Meet the team- Michael Hoffman
- Eric Roberts
- Coby Viner
- Mickael Mendez
- Samantha Wilson
- Linh Huynh
- Annie Lu
- Esther Yoo
- Luomeng Tan
- Veronica Alba
- Natalia Mukhina
News
- 2021-11-11: Michael is a keynote speaker to present at the 2nd Canadian Statistical Sciences Institute (CANSSI) Ontario Workshop on Reproducibility on February 25, 2022.
- 2021-10-28: Rachel and Michael are co-authors on "Segmentation and genome annotation algorithms for identifying chromatin state and other genomic patterns", an article in PLOS Computational Biology.
- 2021-09-25: Michael is a panelist at the virtual panel "Moving from talk to walk: Implementing open science practices at Canadian universities and research institutions" for the 2021 Canadian Science Policy Conference, November 25, 2021.
- 2021-09-02: Sam received the Elsevier Placenta New Investigator award for her talk "A new method to absolutely quantify and enrich for placental DNA from maternal blood using DNA methylation" at the International Federation of Placenta Associations annual meeting.
- 2021-08-30: Michael is a co-author on "Reproducibility standards for machine learning in the life sciences", an article in Nature Methods.
- 2021-08-25: Michael is an invited speaker to present at a Computational Biology Seminar Series at the Garvan Institute of Medical Research in Sydney, Australia, on April 13, 2022.
- News archive
Contact
- Twitter: @michaelhoffman
- LinkedIn: michaelmhoffman