Hoffman research group
- Michael M. Hoffman
- Senior Scientist (principal investigator)
- Research
- Princess Margaret Cancer Centre
- University Health Network
- Associate Professor (status-only)
- Computational Biology Group
- Department of Computer Science
- University of Toronto
We develop machine learning techniques to better understand chromatin biology. These models and algorithms transform high-dimensional functional genomics data into interpretable patterns and lead to new biological insight.
Publications
Software
- Segway: semi-automated genomic annotation
- Segtools: segmentation analysis and graphics
- Genomedata: efficient storage and retrieval
- Umap and Bismap: tools for quantifying mappability of the genome and methylome
- BEHST: biological enrichment of hidden sequence targets
- Virchip: predicting transcription factor binding by learning from the transcriptome
- PeaKO: finding transcription factor binding motifs using knockout controls
Databases
- DNAmod: the DNA modification database
Join the lab
People
Meet the team- Michael Hoffman
- Eric Roberts
- Coby Viner
- Mickael Mendez
- Samantha Wilson
- Linh Huynh
- Annie Lu
- Esther Yoo
- Luomeng Tan
- Veronica Alba
- Natalia Mukhina
News
- 2021-07-16: Michael is a panelist at the 2021 Canadian Science Policy Conference (CSPC 2021).
- 2021-07-15: Michael is a presenter and session chair of the Regulatory and Systems Genomics session at the ISMB/ECCB 2021 conference. His talk covers: "Viral integration transforms chromatin to drive oncogenesis".
- 2021-07-14: Michael was awarded Essential Oncology Software for Research funding from the Princess Margaret Data Science Program, University Health Network.
- 2021-06-22: Michael is a co-author on "Tumor-Naive Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma", an article in Clinical Cancer Research.
- 2021-06-01: Mehran was awarded the CIHR Post-doctoral Fellowship.
- 2021-05-26: Michael is a co-author on a paper titled "Viral integration transforms chromatin to drive oncogenesis" accepted for a talk at the Intelligent Systems for Molecular Biology/European Conference on Computational Biology 2021 Conference (ISMB/ECCB 2021) in July 2021.
- News archive
Contact
- Twitter: @michaelhoffman
- LinkedIn: michaelmhoffman