Description

A nucleobase analogue that is cytosine in which the hydrogen at position 5 is replaced by a carboxy group.

Chemical properties

Chemical formula Net charge Average mass
C5H5N3O3 0 155.11150
5-carboxycytosine

Recommended notation

Name 5-carboxylcytosine
Abbreviation 5caC
Symbol c
Complement guanine:5-carboxylcytosine
Symbol 4

Nomenclature

IUPAC SMILES InChI InChIKey Synonyms
4-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid Nc1nc(=O)[nH]cc1C(O)=O InChI=1S/C5H5N3O3/c6-3-2(4(9)10)1-7-5(11)8-3/h1H,(H,9,10)(H3,6,7,8,11) BLQMCTXZEMGOJM-UHFFFAOYSA-N
  • 4-amino-2-oxopyrimidine-5-carboxylic acid
  • 5-carboxylcytosine
  • cytosine-5-carboxylic acid

Mapping techniques

Method Method detail Resolution
Qualifier
References
CAB-seq chemical conversion single-base
MAB-seq chemical conversion single-base low-input or single-cell
caMAB-seq chemical conversion single-base

Nature

Origin Function Functional detail
Organisms
References
natural demethylation intermediate and possible epigenetic mark
  • Homo sapiens
  • Mus musculus