Description

A nucleobase analogue that is cytosine in which the hydrogen at position 5 is replaced by a formyl group.

Chemical properties

Chemical formula Net charge Average mass
C5H5N3O2 0 139.11210
5-formylcytosine

Recommended notation

Name 5-formylcytosine
Abbreviation 5fC
Symbol f
Complement guanine:5-formylcytosine
Symbol 3

Nomenclature

IUPAC SMILES InChI InChIKey Synonyms
4-amino-2-oxo-1,2-dihydropyrimidine-5-carbaldehyde Nc1nc(=O)[nH]cc1C=O InChI=1S/C5H5N3O2/c6-4-3(2-9)1-7-5(10)8-4/h1-2H,(H3,6,7,8,10) FHSISDGOVSHJRW-UHFFFAOYSA-N
  • 4-amino-2-oxopyrimidine-5-carbaldehyde
  • cytosine-5-carbaldehyde

Mapping techniques

Method Method detail Resolution
Qualifier
References
CLEVER-seq chemical tagging single-base single-cell
MAB-seq chemical conversion single-base
MAB-seq chemical conversion single-base low-input or single-cell
Pvu-seal-seq enzyme-mediated chemical tagging single-base
fC-CET chemical conversion single-base
fCAB-seq chemical conversion single-base
redBS-seq chemical conversion single-base

Nature

Origin Function Functional detail
Organisms
References
natural demethylation intermediate and epigenetic mark
  • Homo sapiens
  • Mus musculus