Description
A methylthymine in which the methyl group is located at the O4-position.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C6H8N2O2 | 0 | 140.140 |
-methylthymine.svg)
Recommended notation
| Name | O4-methylthymine |
|---|---|
| Abbreviation | O4-meT |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 4-methoxy-5-methylpyrimidin-2(1H)-one | C=1(C(=CNC(N1)=O)C)OC | InChI=1S/C6H8N2O2/c1-4-3-7-6(9)8-5(4)10-2/h3H,1-2H3,(H,7,8,9) | NWUTZAVMDAGNIG-UHFFFAOYSA-N |
|
Nature
| Origin | Function | Functional detail |
Organisms
|
References |
|---|---|---|---|---|
| natural | damage | mutagenic | Homo sapiens |
|
Citations
- Aliakbar Tehrani, Z, et al. 2013. Comparison of gas phase intrinsic properties of cytosine and thymine nucleobases with their O-alkyl adducts: different hydrogen bonding preferences for thymine versus O-alkyl thymine. Journal of Molecular Modeling. 19(8).
- Encell, LP, et al. 1999. Redesigning the substrate specificity of human O(6)-alkylguanine-DNA alkyltransferase. Mutants with enhanced repair of O(4)-methylthymine. Biochemistry. 38(37).
- Encell, LP, et al. 2000. Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase. Carcinogenesis. 21(7).
- Fang, Q, et al. 2009. Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases. The Journal of Biological Chemistry. 285(11).
- Kang, H, et al. 1995. Detection of O6-methylguanine, O4-methylthymine and O4-ethylthymine in human liver and peripheral blood leukocyte DNA. Carcinogenesis. 16(6).
- Pauly, GT, et al. 2001. Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair. Chemical Research in Toxicology. 14(7).
- Stoklosa, T, et al. 2008. BCR/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations. Cancer Research. 68(8).